Hematopoietic science
Hematopoietic stem cells sit at the foundation of lifelong blood and immune renewal—and at the center of CELUVIN’s scientific approach.
HSC foundations
The Biological Source of Blood Renewal
Hematopoietic stem cells are rare, self-renewing cells in the bone marrow. Through differentiation, they generate the major cellular components of blood, including red blood cells, platelets and diverse immune cells.
Aging at the source
Aging Can Begin Upstream
Normal aging can involve changes in HSC self-renewal, lineage balance, oxidative stress, inflammatory signaling and the bone-marrow environment. One recurring pattern is increased myeloid bias alongside reduced lymphoid output. These changes are part of a complex aging process and should not be treated as a diagnosis on their own.
Scientific foundation
Expertise with Clear Relationship Boundaries
Professor Zhenyu Ju
CELUVIN’s HSC-focused research direction draws on more than two decades of published work by Professor Zhenyu Ju’s team on stem cell aging, regeneration and hematopoietic biology.
Kris Cai
Background in life sciences and aging research, including study at Fudan University, visiting research experience at Harvard Medical School, and doctoral training at The University of Texas MD Anderson Cancer Center. Role: scientific review, mechanism analysis and product development input.
Aileen Li
Training in biochemistry and biomedical science, including the University of Washington, Harvard Medical School and doctoral research at The University of Texas MD Anderson Cancer Center. Role: literature review and technical advisory input.
Formulation science
From Biological Target to Scientific Formula
- 01
Target selection
Reviewed as a distinct decision in the documented formulation process.
- 02
Literature review
Reviewed as a distinct decision in the documented formulation process.
- 03
Ingredient screening
Reviewed as a distinct decision in the documented formulation process.
- 04
Mechanism evaluation
Reviewed as a distinct decision in the documented formulation process.
- 05
Serving-level and safety assessment
Reviewed as a distinct decision in the documented formulation process.
- 06
Ingredient compatibility
Reviewed as a distinct decision in the documented formulation process.
- 07
Formula design
Reviewed as a distinct decision in the documented formulation process.
- 08
Scientific review
Reviewed as a distinct decision in the documented formulation process.
- 09
Continuous refinement
Reviewed as a distinct decision in the documented formulation process.
- Cellular energy
- Oxidative balance
- Hematopoietic environment
- Immune balance
- Biological resilience
Evidence framework
Evidence Built in Layers
General biology, an individual ingredient, a finished formula and a person’s experience do not establish the same thing.
Biological rationale
Can support: Why HSC biology is relevant to aging research.
Cannot substitute for: Evidence that a CELUVIN product changes outcomes.
Ingredient evidence
Can support: Why an ingredient was considered.
Cannot substitute for: Evidence for the finished formula.
Formulation evidence
Can support: Data generated on a finished CELUVIN formula.
Cannot substitute for: A randomized clinical trial unless the study actually is one.
Real-world experience
Can support: How users describe energy, sleep or recovery.
Cannot substitute for: Objective biomarkers or medical outcomes.
Objective data
- Measured cell-population ratios
- Laboratory indicators
- Study outcomes
- Quantitative change
Lived experience
- Energy and day-to-day vitality
- Sleep experience
- Recovery experience
- Individual perception
Preliminary product-use observations
Transparent Before Promotional
Preliminary product-use observations are being organized for transparent publication.
Specific percentages remain unpublished until participant criteria, sample size, measurement methods, missing-data handling, statistical analysis, full results and limitations are available together.
Selected publications
Peer-Reviewed Research
Selected research involving Professor Zhenyu Ju.
Protein & Cell, 2024, 15: 840–857
p21/Zbtb18 repress the expression of cKit to regulate the self-renewal of hematopoietic stem cells
10.1093/procel/pwae022Cell Research, 2018, 28: 1035–1038
Loss of YTHDF2-mediated m6A-dependent mRNA clearance facilitates hematopoietic stem cell regeneration
10.1038/s41422-018-0082-yCell Research, 2018, 28: 323–335
Eosinophil-derived CCL-6 impairs hematopoietic stem cell homeostasis
10.1038/cr.2018.2Nature Metabolism, 2021, 3: 1706–1726
The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice
10.1038/s42255-021-00491-8Intellectual property
Patent Applications
Application of glycyrrhetinic acid in the prevention and treatment of stem cell aging
- Application
- 202010406649.9
- Applicant
- Ningbo Heren Health Technology Co., Ltd.
- Inventors
- Zhenyu Ju, Jianxin Chen, Fan Yang
- Published
- 13 October 2020
A method for assessing hematopoietic system aging
- Application
- 202510628311.0
- Applicant
- Jinan University
- Inventors
- Yuanlong Ge, Zhenwen Chen, Shu Wu, Zhenyu Ju, Shenghao Xie
- Published
- 29 August 2025